New THE MATHEMATICA JOURNAL article:
Designing siRNAs for Gene Silencing
by Todd D. Allen
ABSTRACT: Biological systems possess traits that are a product of coordinated gene expression, heavily influenced by environmental pressures. This is true of both desirable and undesirable traits (i.e. disease). In cases of unwanted traits, it would be tremendously useful to have a means of systematically lowering the expression of genes implicated in producing the undesirable traits. This article describes the implementation of a computational biology algorithm designed to compute small interfering RNA sequences, capable of systematically silencing the expression of specific genes.
