Since my Mathematica 10.2 installation CD only lists Windows Vista/7/8 the obvious answer is ‘no’.
But I would like to know whether other Windows 10 users encounter the same problems:
I can’t interact with Wolfram Demonstrations (they ask me to install the CDF Player although the latest version is installed).
Further, I can’t access my printer from Mathematica (although other installed non-MS programs, such as OpenOffice Writer, allow this).
Also surprising: in text input sometimes the insert mode gets lost, as does the cursor.