It's very annoying but I found a fix with up to now no side effects.
It seem that the .nb extension has no iFilter driver linked. I believe this could just be the standard .TXT.
Windows 10 and MM12.o
You can start regedt32 from the windows run prompt.
Go to the
Computer\HKEYLOCALMACHINE\SOFTWARE\Classes.txt\PersistentHandler
Double click on the Default item and copy the GUID in my case as an example:
{5e941d80-bf96-11cd-b579-08002b30bfeb}
Go to the
Computer\HKEYLOCALMACHINE\SOFTWARE\Classes.nb\PersistentHandler
Double click on the Default item and Paste the GUID from the .txt (In my case there was no GUID entry in the Default entry which I guess triggers the "not registered message"..?)
That's it and it worked for me. Would love to hear official Support statement from Wolfram though..
I also noted that for the .m and .ma files the same entries are used and these already worked as already explained by the OP.