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Robert Rimmer

[Notebook] Updated: coronavirus logistic growth model: China

Robert Rimmer

Posted 1 year ago

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MODERATOR NOTE: coronavirus resources & updates: https://wolfr.am/coronavirus

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On 29 February 2020, the China National Health Commission reported 423 new cases of coronavirus for Hubei and only 4 cases for the rest of the country. The logistic function fit to the data from the Johns Hopkins CSSE, have been showing for a while that the epidemic should end outside of the Hubei province in the first week of March. The recent report seems to confirm this prediction.

This notebook contains some updated and new functions that were not in my previous posts.

Data Source

https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

The latest data gets updated on dashboard above before it is loaded to GitHub, which is the source for the notebook.

https://github.com/CSSEGISandData/COVID-19/tree/master/csse_covid_ 19_data/csse_covid_ 19_time _series

Procedures

In[]:=

Clear[modelFitDisplay];modelFitDisplay[NLM_,data_,opts___]:=Module[{bands,p0,p1},bands[t_]=NLM["SinglePredictionBands",ConfidenceLevel0.95];p0=Plot[{NLM[t],bands[t]},{t,1,data[[-1]][[1]]+5},opts,Filling{2{1}},PlotStyle{Darker@Red,Darker@Orange,Darker@Orange},GridLinesAutomatic,PlotRangeAll,opts];p1=ListPlot[Tooltip[#,#]&/@data,PlotRangeAll];Show[p0,p1]];

In[]:=

Clear[derivativeDisplay];derivativeDisplay[NLM_,data_,opts___]:=Module[{daynum,end,peak},daynum=data[[-1]][[1]];peak=t0/.NLM["BestFitParameters"];end=x/.FindRoot[NLM'[x]1,{x,peak,peak+200},(*forcetorighttail*)Method"Brent"][[1]];Print["Last case: ",DateString[DatePlus[{2020,1,21},Ceiling@end],"DateShort"]];Show[Plot[{NLM'[x],NLM''[x]},{x,data[[1]][[1]]-4,daynum+5},opts,GridLinesAutomatic,PlotRangeAll,PlotLegends{"First Derivative","Second Derivative"}],ListPlot[Tooltip[#,#]&/@{{daynum,NLM'[daynum]}},PlotStyle{Red,PointSize[0.02]}]]];

In[]:=

Clear[dataD1];dataD1[data_,{k_,L_}]:=Table[{data[[i]][[1]],kdata[[i]][[2]](1-data[[i]][[2]]/L)},{i,Length[data]}];

In[]:=

logistic=L/(1+Exp[-k(t-t0)]);

In[]:=

Clear[logisticDEFit];logisticDEFit[data_,graphic_:True,optsInterpolation___]:=Module{dataFn,dataDE,dataDEPlot,deModel,deNLM,bands},dataFn=Interpolation[data,optsInterpolation,Method"Spline"];dataDE={dataFn[#],dataFn'[#]}&/@data[[All,1]];dataDEPlot=ListPlot[dataDE,PlotStyleDarker@Red,GridLinesAutomatic,PlotRangeAll];deModel=kx1-

;deNLM=NonlinearModelFit[dataDE,deModel,{k,L},x];If[graphic,bands[L_]=deNLM["SinglePredictionBands",ConfidenceLevel0.95];Print@Show[Plot[{deNLM[x],bands[x]},{x,0,L/.deNLM@"BestFitParameters"},GridLinesAutomatic,Filling{2->{1}},FrameTrue,FrameLabel{"Cases","New Cases Per Day"},PlotRangeAll,PlotLabel"Logistic Differential Equation"],dataDEPlot]];Flatten@{deNLM@"BestFitParameters",FindRoot[dataFn[t0]L/2/.deNLM["BestFitParameters"],{t0,data[[-1]][[1]]}]};

Import Data

In[]:=

deaths=Import["https://raw.githubusercontent.com/CSSEGISandData/COVID-19/master/csse_covid_19_data/csse_covid_19_time_series/time_series_19-covid-Deaths.csv"];deaths[[1]][[-1]]

Out[]=

2/28/20

In[]:=

deathData=AssociationThread[First@deaths,#]&/@Rest[deaths]//Dataset;

In[]:=

confirmed=Import["https://raw.githubusercontent.com/CSSEGISandData/COVID-19/master/csse_covid_19_data/csse_covid_19_time_series/time_series_19-covid-Confirmed.csv"];confirmed[[1]][[-1]]

Out[]=

2/28/20

Setup Datasets

In[]:=

caseData=AssociationThread[First@confirmed,#]&/@Rest[confirmed]//Dataset;

In[]:=

chinaCaseData=caseData@Select[#"Country/Region""Mainland China"&];chinaDeathData=deathData@Select[#"Country/Region""Mainland China"&];

In[]:=

keys=Keys[First@Normal@caseData];Keys[First@Normal@deathData];

In[]:=

deathCases=Transpose[{Range[Length@keys-4],Values@Normal[chinaDeathData[Total,Drop[keys,4]]]}];confirmedCases=Transpose[{Range[Length@keys-4],Values@Normal[chinaCaseData[Total,Drop[keys,4]]]}];

In[]:=

notHubeiData=chinaCaseData@Select[#"Province/State"≠"Hubei"&];notHubeiCases=Transpose[{Range[Length@keys-4],Values@Normal[notHubeiData[Total,Drop[keys,4]]]}];

In[]:=

hubeiData=chinaCaseData@Select[#"Province/State""Hubei"&];hubeiCases=Transpose[{Range[Length@keys-4],Values@Normal[hubeiData[All,Drop[keys,4]]][[1]]}];

China Death Data

In[]:=

deathsNLM=NonlinearModelFit[deathCases,logistic,{{k,0.3},{L,3000},{t0,25}},t];deathsNLM@"BestFitParameters"

Out[]=

{k0.172041,L3044.88,t024.2041}

Out[]=

In[]:=

deathsNLM@"ParameterConfidenceIntervalTable"

Out[]=

	Estimate	Standard Error	Confidence Interval
k	0.172041	0.00394588	{0.16403,0.180052}
L	3044.88	41.6121	{2960.4,3129.36}
t0	24.2041	0.226153	{23.745,24.6632}

The graphic below shows the first and second derivative plots of the logistic function. The red dot is at the current day number on the first derivative curve. The green dots are the points calculated by the logistic differential equation, using each data point. The prediction for the last case date is printed (probably not accurate until there are at least three weeks of new data).

Last case: Sun 22 Mar 2020

Out[]=

	First Derivative
	Second Derivative

China Clinical Cases

In[]:=

casesNLM=NonlinearModelFit[confirmedCases,logistic,{{k,0.3},{L,80000},{t0,25}},t];casesNLM@"BestFitParameters"

Out[]=

{k0.221968,L80902.5,t018.7671}

Out[]=

In[]:=

casesNLM@"ParameterConfidenceIntervalTable"

Out[]=

	Estimate	Standard Error	Confidence Interval
k	0.221968	0.0103505	{0.200955,0.24298}
L	80902.5	1230.14	{78405.2,83399.8}
t0	18.7671	0.265818	{18.2274,19.3067}

Last case: Tue 24 Mar 2020

Out[]=

	First Derivative
	Second Derivative

China Cases Outside Hubei

In[]:=

notHubeiNLM=NonlinearModelFit[notHubeiCases,logistic,{{k,0.3},{L,15000},{t0,25}},t];notHubeiNLM@"BestFitParameters"

Out[]=

{k0.25761,L12801.6,t013.4586}

Out[]=

In[]:=

notHubeiNLM@"ParameterConfidenceIntervalTable"

Out[]=

	Estimate	Standard Error	Confidence Interval
k	0.25761	0.00547199	{0.246502,0.268719}
L	12801.6	62.0486	{12675.7,12927.6}
t0	13.4586	0.0955942	{13.2645,13.6526}

Last case: Fri 6 Mar 2020

Out[]=

	First Derivative
	Second Derivative

China Hubei Cases

In[]:=

hubeiNLM=NonlinearModelFit[hubeiCases,logistic,{{k,0.3},{L,15000},{t0,25}},t];hubeiNLM@"BestFitParameters"

Out[]=

{k0.235356,L67672.4,t019.6809}

Out[]=

In[]:=

hubeiNLM@"ParameterConfidenceIntervalTable"

Out[]=

	Estimate	Standard Error	Confidence Interval
k	0.235356	0.0127775	{0.209417,0.261296}
L	67672.4	1189.32	{65257.9,70086.8}
t0	19.6809	0.292337	{19.0874,20.2744}

Last case: Sun 22 Mar 2020

Out[]=

	First Derivative
	Second Derivative

Fitting to the Logistic Differential Equation

These graphics show a method of fitting to the equation for the logistic first derivative.

f'[t]=kx1-

The value of x is the number of cumulative cases. This is a quadratic equation with roots at x = 0 and x = L, and peak at x = L/2. The first derivative is obtained from the data by making an interpolation function (Method  “Spline” is default) from the data then using the function to calculate first derivative at each point. The 95% confidence intervals are shown for the quadratic fit. Clearly the data sets show quite a lot of irregularity by this method. The smoother data set, notHubei, shows the later points becoming more accurate. The parameters are similar to the fit to the logistic function.

In[]:=

logisticDEFit[deathCases]

Out[]=

{k0.167235,L3097.5,t024.2121}

In[]:=

logisticDEFit[confirmedCases]

Out[]=

{k0.221009,L80819.9,t019.2458}

In[]:=

logisticDEFit[notHubeiCases]

Out[]=

{k0.252988,L12850.2,t045.7223}

In[]:=

logisticDEFit[hubeiCases]

Out[]=

{k0.237076,L67516.9,t022.0443}

POSTED BY: Robert Rimmer

Answer

7 Replies

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Mads Bahrami

Mads Bahrami, Wolfram Research Inc

Posted 1 year ago

Thanks a lot Robert! I really enjoy reading it. I wonder why you have used interpolation to get dataDE in your function logisticDEFit? For example, look at this notebook where I compare my suggestion with your interpolation data:

POSTED BY: Mads Bahrami

Answer

Robert Rimmer

Posted 1 year ago

POSTED BY: Robert Rimmer

Answer

Mads Bahrami

Mads Bahrami, Wolfram Research Inc

Posted 1 year ago

Thanks for your input! Well-explained!

POSTED BY: Mads Bahrami

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Moderation Team

Moderation Team, WOLFRAM

Posted 1 year ago

-- you have earned *Featured Contributor Badge* Your exceptional post has been selected for our editorial column *Staff Picks* http://wolfr.am/StaffPicks and Your Profile is now distinguished by a *Featured Contributor Badge* and is displayed on the Featured Contributor Board. Thank you, keep it coming, and consider contributing to the The Notebook Archive!

POSTED BY: Moderation Team

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Robert Rimmer

Posted 1 year ago

I posted a notebook tying the SEIR model to the Logistic model: LogisticFromSEIR

POSTED BY: Robert Rimmer

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Updating Name

Posted 1 year ago

Hi, I really appreciate the job you did. I use to use statistics in my professional activity, and I'm quite familiar with problems concerning the "bayesian calibration of computer code outputs". Since a few weeks I'm analysing the data about the CoVid19 outbreak and one of my main question is "how can we infer the value of the mortality rate" ? This is not a trivial problem and I think that bayesian inference (I don't know if you are familiar with this topic?) could enable estimating the distribution of "credible" mortality rates. Do you have some knowledge about works concerning this approach? df

POSTED BY: Updating Name

Answer

Robert Rimmer

Posted 1 year ago

Right now I don't think the problem can be solved. Deaths are easy to count and because they were ill first most all were tested, but the number of infected people is determined by testing, which has varied widely by location and indication. Until there has been surveillance testing in a large community to know the incidence and prevalence of infection, I don't think you can estimate probabilities needed for Bayesian inference.

POSTED BY: Robert Rimmer

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