The following expression should simplify to 1, but instead it is returned unevaluated:
Mathematica 12.1.0 Kernel for Linux x86 (64-bit)
Copyright 1988-2020 Wolfram Research, Inc.
In[1]:= $Assumptions = a>0 && b>0
Out[1]= a > 0 && b > 0
In[2]:= Sqrt[a+I*b]*Conjugate[1/Sqrt[a-I*b]] // FullSimplify
1
Out[2]= Sqrt[a + I b] Conjugate[-------------]
Sqrt[a - I b]
Note that the equivalent code in Maxima evaluates to 1 as expected:
(%i2) assume(a>0,b>0);
(%o2) [a > 0, b > 0]
(%i3) sqrt(a+%i*b)*conjugate(1/sqrt(a-%i*b));
(%o3) 1