Here is a way:
myMatrix = RandomInteger[{-3, 3}, {4, 4}];
reg = ImplicitRegion[
And @@ Thread[myMatrix . {x1, x2, x3, x4} <= 0], {x1, x2, x3, x4}]
pt = {x1, x2, x3, x4} /.
First@FindInstance[
And @@ Thread[myMatrix . {x1, x2, x3, x4} <= 0] && x1 < 0, {x1,
x2, x3, x4}]
RegionMember[reg, pt]