In[5]:= Assuming[Element[{n1, n2, n3}, Integers], FractionalPart[n1 + 2 n2 - 3 n3 ]]
Simplify[FractionalPart[n1 + 2 n2 - 3 n3], Element[{n1, n2, n3}, Integers]]
Out[5]= FractionalPart[n1 + 2 n2 - 3 n3]
Out[6]= 0
Why does the "Assuming" approach not work?
You have used the infix form [Epsilon], it should be [Element].
Thank you for pointing out my misuse of mathematical symbols. The shapes of these two symbols are so similar that I really didn't notice their differences.