I posted a question on SE http://mathematica.stackexchange.com/questions/57247/manipulate-crashes-after-running-4-minutes dealing with possible memory leakage when running manipulate.
I would be grateful for some feedback.
OSX 10.9.4 Mathematica 10.0.0.0 MBP 2.6 GHz Intel Core i7 16 GB 1600 Mhz DDR3