To run the Mathematica runtime directly on the PYNQ board, you’ll have to cross-compile Wolfram libraries for ARM.
Wolfram Mathematica does not natively provide ARM-compatible libraries (libWolframRTL.so) for ARM platforms such as the PYNQ board. The libraries provided by Wolfram are typically built for x86-64 Linux systems, which causes the architecture mismatch when you try to use the ARM cross-compiler (arm-linux-gnueabihf-gcc).
In this, ARM-compatible libraries from Wolfram are required. Or please provide a custom solution or suggest alternatives.