Jose,
2 problems with your update. You have a typo in 2 places: y^'' should just be y''
Also, you should not specify initial conditions on x''' because it is determined from an equation. Same for y''. Both are not valid initial conditions. (see @Gianluca Gorni post above)
This works: (as would any combination of initial conditions that does not involve x''' nor y'')
NDSolve[{x'''[t] == x[t] Derivative[1][y][t],
y''[t] == -(1/(x[t]^2 + y[t]^2)), x[0] == 1, x''[0] == 0,
y[0] == 1/8, Derivative[1][y][0] == 0, y'[0] == 1/2}, {x, y}, {t, 0,
1}]
Regards