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A SEIRD Model For COVID-19 Using DDEs

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POSTED BY: Luis Borgonovo
10 Replies

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POSTED BY: EDITORIAL BOARD

Thank you for the reference Christopher! I downloaded it already to check it out. I will comment further afterwards, if I can make some progress with this other approach.

POSTED BY: Luis Borgonovo
POSTED BY: Luis Borgonovo

Hi Robert & Luis --

I think the instability is due to the way you've formulated the delay. Instead of individuals leaving the infected pool at rate I[t-tau], I think you need something like eq. (5.1) in this paper, although they put a fixed duration in E, not I.

Forgot to mention, I did try to include the mu term in the infectious equation but it was very unstable, so in the end I thought did not worth the trouble.

POSTED BY: Luis Borgonovo

It might work, I tried different nonlinear terms but I didn't think on using log(S), thank you for the feedback, I will check it out!

POSTED BY: Luis Borgonovo
POSTED BY: Daniel Lichtblau

Thanks Robert! I share your concern about the reduced total population, something I briefly comment in the Discussion, and I’ve been thinking about ways to do it in a less artificial way, but still working on it. I thought about sharing the results of this approach, just to show its pros and cons.

I haven’t tried what you are suggesting, I will check and comment you back soon, in a few days :-)

POSTED BY: Luis Borgonovo

Nice post! I'm glad you had better success fitting the data than I did, and the comparison of several countries with quite varied mitigation strategies is interesting.

I'm still concerned that the total population has to be made so small, and we should be able to devise a model that effectively reduces the number of susceptible individuals in a mechanistically plausible manner.

The time delays, in principle, replace the duration of infection and time to death, and therefore the rate constants [Gamma] and [Mu] shouldn't be needed. Have you tried fitting the data without them?

Looking at the summary table, [Gamma] isn't much greater that [Mu], only a factor of 15-30 for the different fits, so the equation for I should still include the term for death. Did you try modeling without making that assumption?

It seems that mathematician like to make these kinds of simplifications so that the system can be linearized, and additional statements about steady states and stability can be made more easily. With the capabilities of WL, I don't think that's necessary and we can get sufficiently accurate answers to those questions with simulation. Sometimes these simplifications are made to reduce the number of parameters, but again it's almost trivial to get sensitivities and and one can still maintain sufficient rigor in parameter fitting by making use of proper identifiability analysis.

POSTED BY: Robert Nachbar
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