Currently, the prize for Megamillions is over a billion dollars. Pick 5 numbers from 1 to 70, then pick one number from 1 to 25.
Odds of winning Megamillions:
25 Binomial[70, 5] = 302575350
Not sure what the odds are of just one winner or no winners.
You can generate numbers with the following.
Append[RandomSample[Range[70], 5], RandomInteger[{1, 25}]]
{67, 51, 34, 25, 9, 10}
