In 14.0? No. The only option is setting the Magnification globally to 75%. In 13.3 and earlier, you can opt back into the compatibility mode via CurrentValue[$FrontEnd, "ScreenResolutionCompatibilityMode"] = True.
The results from SystemInformation are in points (1/72nd of an inch), not pixels. If you do the conversion, they match the pixel dimensions of your display.
