Many ways to do it. This is one:
DynamicModule[{f = Plus, a = 1, b = 1, c = 2},
Column[
{RadioButtonBar[Dynamic[f], {Plus, Subtract, Times, Divide}],
Grid[
{{InputField[Dynamic[a]], "First Number"},
{InputField[Dynamic[b]], "Second Number"},
{InputField[Dynamic[c], Enabled -> False], "Result"}}],
Button["Calculate", c = f[a, b]]}]]
Buena suerte!