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My guess would be that 100GB you may be forced to keep it in a database structure for initial filtering and maybe convert the subsets to Key-Value, though 10GB is still a huge dataset. Please post your end-solution. Thanks
This is a huge omission from Mathematica. When trying to get other's on board with Mathematica, the lack of the feature creates a huge frustration for the new users. Coding a 2nd y-axis leaves them scrambling back to Matlab or Excel.