Your question is not clearly enough framed. For example, do you want to consider the issue of cost? (Mathematica is very expensive, although not necessarily more expensive than a certain other mathematical system M****b.) Or whether the code is open-source vs. proprietary? (Most of Mathematica's code is proprietary.)
Or are you asking only about inherent properties of the product?
For the latter, do you want to highlight benefits and difficulties as compared with those of another application? For example, Mathematica for the most part uses verbose names for built-in functions and other entities, while rival products tend to use rather short names. (So it's a matter of using memorable names but having to type more characters vs. often cryptic names but typing less.)
If you do want to make a comparison, which your question suggests but does not directly say, then the best way would be to take one or two specific examples of something you want to do and then do it in Mathematica, on the one hand, and in some competing application(s), on the other hand. Otherwise, general statements about benefits and difficulties can be non-transparent.
