Some tips I remembered tonight:
One cool detail of the Wolfram Language & System Documentation Center is searching on a shortcut. If you put a shortcut into the search box (e.g., //, #, &, /@, etc.) you will go to a page documenting both the shortcut and non-shortcut forms of the shortcut.
Doing the non-shortcut form -- invoking the function with no shortcuts -- is essential to mastering the shortcut. I like saying the full name of a shortcut to myself whenever using one.
The documentation can be brought up as a window in the Mathematica App, or it can be found on the web at https://reference.wolfram.com/language/ . At different times, one way or the other will be better for consulting the docs.
When using the framework, there are times when it's easier to have one of the framework windows in its own tab. On the Mac, you can right-click in a window and select "Open Frame in New Tab". I'm guessing there is a similar way to do this on Windows and Linux.
NotebookDelete[Cells[]] will erase everything in the scratch notebook.