Hi Jason,
in this particular case the solution is obviously not unique. The following line for example:
FindInstance[387381625547900583936 == x*2^y && x \[Element] Reals && y \[Element] Reals, {x, y}]
finds
{{x -> 84, y -> Log[4611686018427387904]/Log[2]}}
which numerically evaluates to
{{x -> 84., y -> 62.}}
This obviously is a valid solution. Not you also see what the pattern is. All these pairs fulfil your equation:
Table[{387381625547900583936/2^n, n}, {n, 0, 64}]
as can be seen from
#[[1]]*2^#[[2]] & /@ Table[{387381625547900583936/2^n, n}, {n, 0, 64}]
You can of course also get an idea of this behaviour of you use:
FactorInteger[387381625547900583936]
The result
{{2, 64}, {3, 1}, {7, 1}}
tells you that this is 21*2^64.
Cheers,
Marco